Metastasis-specific gene expression in autochthonous and allograft mouse mammary tumor models: stratification and identification of targetable signatures

Transcriptomic study of metastases generated by many of the most widely used mouse models of breast cancer metastasis Overall design: Paired primary tumor and metastatic tissues were collected from several mouse models of metastatic breast cancer. RNA sequencing was then performed in order to characterize the differences between metastasis-specific gene expression in different models, and also to identify shared metastasis-specific transcriptomic characteristics.