Extensive diversity and impact of drug-resistant HIV-1 variants in individuals with prior virologic failure

Raw sequencing data from HIV-1 samples obtained from individuals with a history of virologic failure on first-line antiretroviral therapy. Viral RNA was amplified using targeted PCR approaches and sequenced to characterize drug resistance mutations and linked variant haplotypes. The dataset includes high-depth amplicon sequencing generated using Illumina 2x300 sequencing. These data were used to assess the diversity, frequency, and clinical impact of drug-resistant HIV-1 variants.