Transcriptomic analysis of mouse subcutaneous tumor after intratumoral treatment with SLR14 or vehicle

We subcutaneously injected 5x105 YUMMER1.7 melanoma into right flank of C57BL/6J mice. 7 days later, the mice were intratumorally treated with 1 mg/kg SLR14 or vehicle every 3 days, for a total of 3 cycles. We observed a significant tumor growth delay in SLR14-treated mice compared to vehicle-treated mice. The tumors were intratumorally treated with 1 mg/kg SLR14 or vehicle. After 3 cycles of treatment, tumors were harvested and total RNAs were extraced.