Hydroxychloroquine inhibits trained immunity
收藏NIAID Data Ecosystem2026-03-12 收录
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资源简介：
We demonstrate that hydroxychloroquine inhibits trained immunity at the functional and epigenetic level and is accompanied by reduced expression of interferon-stimulated genes. Trained immunity comprises a functional adaptation induced by epigenetic reprogramming which facilitates the anti-viral innate immune response. Overall design: We performed ChIP sequencing and RNA sequencing on trained monocytes that are treated with HCQ, and RNA-seq on monocytes from COVID-19 patients that were treated with HCQ.
创建时间：
2021-01-21
