Computational analysis on individuals on warfarin.

*Plasma composition data from individuals on warfarin and a control group (n = 5) were used to construct computational thrombin generation profiles from which thrombin parameters clot time, maximum rate of thrombin generation (Max Rate), maximum level of thrombin generation (Max Level) and total thrombin (AUC) were extracted. The parameter data are presented as mean (SD) for either a ratio or a percentage between warfarin treated and control individuals.†One individual studied at eight separate times over a six month period.‡47 anticoagulated patients were divided into two groups based on their INR and their thrombin generation modeled. Thrombin parameters were extracted and compared to the control group (n = 32) as in study 1.