Crystal structure of TEAD1-YBD in complex with irreversible compound SWTX-143
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Crystal structure of TEAD1-YBD in complex with irreversible compound SWTX-143 Descriptor: Transcriptional enhancer factor TEF-1, ~{N}-[(3~{S})-5-azanyl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2~{H}-quinolin-3-yl]propanamide Authors: Ciesielski, F, Spieser, S.A.H, Marchand, A, Gwaltney, S.L. Deposit date: 2023-08-11 Release date: 2023-10-04 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.58 Å) Cite: A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models. Mol.Cancer Ther., 23, 2024
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2023-08-11
