Alignments of PSGs along with the crucial primate nodes

Comparative analysis of primate genomes within a phylogenetic context is crucial for understanding the evolution of human genetic architecture and the diversity of primates. Here, we present a phylogenomic study of 50 primate species spanning 38 genera and 14 families, including 27 new genomes first reported in this study with many from previously less represented groups, the New World monkeys and Strepsirrhini. Our analyses reveal heterogeneous rates of genomic rearrangement and gene evolution across primate lineages. Thousands of genes were under positive selection in different lineages that have roles in the nervous, skeletal and digestive systems and may have contributed to primate innovations and adaptations. Our study reveals many key genomic innovations occurred in the Simiiformes ancestral node that may have profound impacts on the radiation of Simiiformes and human evolution.