Supplementary materials: The societal impact of early intensified treatment in patients with Type 2 diabetes mellitus

These are peer-reviewed supplementary materials for the article 'The societal impact of early intensified treatment in patients with Type 2 diabetes mellitus' published in the Journal of Comparative Effectiveness Research.Figure S1: Fitted parametric distributions for time to treatment failure in the early intensified treatment groupFigure S2: Fitted parametric distributions for time to treatment failure in the stepwise approach groupTable S1: 6-month probabilities of complication events per treatment scenario [1,2]Table S2: Input parameters for the socioeconomic valuationTable S3: Parameter Variation in DSATable S4: Parameter Variation in PSATable S5: Age and gender distributionTable S6: Number of total complication events per treatment strategyTable S7: Avoided productivity losses per avoided event for each complicationTable S8: Societal Impact variation when parameters were varied to their lower and upper bound in the DSAAim: The current study estimates the societal impact of early intensified treatment compared with initial monotherapy with subsequent treatment intensification in newly diagnosed adults with Type 2 diabetes mellitus in Mexico. Methods: An individual patient-level simulation and a static cohort model were employed to simulate the treatment pathway and the probability of experiencing complications of diabetes. The avoided number of events was translated into avoided productivity losses, which were monetized using wages. Results: Patients on early intensified treatment experienced approximately 13,000 fewer complication events over 10 years. This was translated into a societal impact of $54 million (USD). Conclusion: Early treatment intensification is likely to be of particular benefit to health outcomes and productivity losses.

本数据集为发表在《比较疗效研究杂志》上的文章《对2型糖尿病患者在早期强化治疗中的社会影响》的同行评审补充材料。图S1：早期强化治疗组治疗失败时间拟合的参数分布图；图S2：逐步方法组治疗失败时间拟合的参数分布图；表S1：[1,2]每种治疗方案下6个月并发症事件的发生概率；表S2：社会经济评估的输入参数；表S3：DSAT参数的变异；表S4：PSAT参数的变异；表S5：年龄和性别分布；表S6：每种治疗方案下总并发症事件数；表S7：每个并发症事件避免的生产力损失；表S8：在DSAA中参数在其下限和上限变化时的社会影响变化。研究目的：本研究旨在估计与墨西哥新诊断的2型糖尿病患者初始单药治疗随后强化治疗相比，早期强化治疗的社会影响。研究方法：采用个体患者层面的模拟和静态队列模型来模拟治疗途径和糖尿病并发症发生的概率。将避免的事件数转换为避免的生产力损失，并使用工资进行货币化。研究结果：接受早期强化治疗的病人在10年内并发症事件减少了约13,000次。这转化为社会影响约为5,400万美元（美元）。研究结论：早期治疗强化可能对健康结果和生产力损失具有特别显著的益处。