Supplementary Material for: Long-term observation of focal segmental glomerulosclerosis after treatment of renal parenchymal malakoplakia: a case report

Introduction. Malakoplakia is a rare and chronic granulomatous disease that is pathologically characterized by the presence of Michaelis–Gutmann bodies and large macrophage clusters. Malakoplakia of the renal parenchyma is especially rare. In this report, we describe the long-term prognosis of a patient who was diagnosed with and treated for renal parenchymal malakoplakia in infancy.
Case Presentation. Seventeen years after malakoplakia onset, the patient presented to us with worsening proteinuria. Computed tomography revealed structural abnormalities in the kidney, and focal segmental glomerulosclerosis (FSGS) was diagnosed based on renal biopsy findings. No Michaelis–Gutmann bodies were observed in von Kossa-stained biopsy specimens. Regular outpatient monitoring during the next 9 years showed gradual deterioration of renal function and a moderately high protein/creatinine ratio.
Conclusion. Our findings suggest that structural changes due to malakoplakia can cause focal segmental glomerulosclerosis. Moreover, structural changes indicate the healing of malakoplakia in infancy and the disappearance of its characteristic lesions over time. Owing to its long-term observation period, this unique case provides new insights into the outcomes of patients with renal parenchymal malakoplakia.