Supplementary Table 5 from Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma

Figshare2015-09-01 更新2026-04-28 收录

数据链接：

https://figshare.com/articles/dataset/Supplementary_Table_5_from_Synthetic_Lethal_Approaches_Exploiting_DNA_Damage_in_Aggressive_Myeloma/22531355 数据链接链接失效反馈

官方服务：

资源简介：

Supplementary Table 5. Multivariate analysis of survival groups.

创建时间：

2015-09-01

Enhancing transcription replication conflict targets ecDNA positive cancers. Enhancing transcription replication conflict targets ecDNA positive cancers

ecDNA靶向治疗

合成致死治疗

Extrachromosomal DNA (ecDNA) presents a major challenge for cancer patients. EcDNA renders tumours treatment-resistant by facilitating massive oncogene transcription and rapid genome evolution, contri

NIAID Data Ecosystem70

Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators

合成致死治疗

PARP1抑制剂治疗

Synthetic lethality has been proposed as a way to leverage the genetic differences found in tumor cells to affect their selective killing. Cohesins, which tether sister chromatids together until anaph

NIAID Data Ecosystem50

Aurora A kinase Inhibition Reprograms Metabolism dependent on PGC1α to Drive Synthetic Lethality with Fatty Acid Oxidation Inhibition in Glioblastoma [ATAC-Seq]. Aurora A kinase Inhibition Reprograms Metabolism dependent on PGC1α to Drive Synthetic Lethality with Fatty Acid Oxidation Inhibition in Glioblastoma [ATAC-Seq]

胶质母细胞瘤代谢重编程

合成致死治疗

By integration of transcriptome, CHIP-seq, ATAC-seq, proteomic and metabolite screening followed by carbon tracing (U-13C-Glucose, U-13C-Glutamine and U-13C-Palmitic acid) and extracellular flux analy

NIAID Data Ecosystem20

Inhibition of the STAT3/Fanconi anemia axis by Nifuroxazide is synthetic lethal with PARP inhibition and selectively targets breast cancer stem cells

合成致死治疗

乳腺癌干细胞

Source Data

Figshare2025-03-05 更新60

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality [RNA-Seq]. CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality [RNA-Seq]

前列腺癌分子机制

合成致死治疗

Biallelic loss of cyclin-dependent kinase 12 (CDK12) defines a unique molecular subtype of metastatic castration resistant prostate cancer (mCRPC). It remains unclear, however, whether CDK12 loss per

NIAID Data Ecosystem20

Supplementary Table 5 from Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma

资源简介：

相关数据集