Parameter estimates of the final population model.

Definition of abbreviations: Emax = maximal effect of the drug; A50 = amount of acetazolamide that instantaneously induces 50% of putative maximal effect on serum bicarbonate; Bicar0 = bicarbonate baseline level; MV0 = minute ventilation at baseline level; PaCO20 = PaCO2 at baseline level; BSV = between-subject variability; kout = first-order constant rate for acetazolamide effect kinetics; %rse = percent relative standard error; SAPS II = simplified acute physiology score II at intensive care unit admission; NA = not applicable; Furosemide50 = amount of furosemide that instantaneously induces 50% of putative maximal effect on serum bicarbonate.