The Pathogen-Host Interactions Database, version 4.12

PHI-base is an online database (available at phi-base.org) that catalogues experimentally verified pathogenicity, virulence and effector genes from fungal, oomycete and bacterial pathogens, which infect animal, plant, fungal and insect hosts. PHI-base is a valuable resource in the discovery of genes in medically and agronomically important pathogens, which may be potential targets for chemical intervention. Each entry in PHI-base is curated by domain experts and is supported by strong experimental evidence (for example, gene disruption and gene complementation experiments), as well as literature references in which the original experiments are described. Each gene in PHI-base is presented with its nucleotide sequence and deduced amino acid sequence, as well as a detailed description of the predicted protein's function during the host infection process. To facilitate data interoperability, we have annotated genes using controlled vocabularies and links to external sources (UniProt, Gene Ontology, Enzyme Commission, NCBI Taxonomy, EMBL, PubMed and FRAC). The PHI-base dataset is published as a single table in CSV format (comma-separated values). The data contains information from 4,387 publications, covering 18,190 pathogen–host interactions and 8,411 genes across 279 pathogen species and 228 host species.