Gene expression changes of 1-amino-2,4-dibromoanthraquinone-induced in renal cortex of rats

This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with 1-amino-2,4-dibromoanthraquinone, and the gene expression profiles of renal cortex were analyzed using custom microarrays.本研究旨在建立一种基于致癌物染毒大鼠基因表达谱（gene expression profile）的短期高精度肾脏致癌性预测方法。本研究以1-氨基-2,4-二溴蒽醌对雄性SD（Sprague Dawley）大鼠开展28天重复给药实验，并采用定制微阵列（custom microarrays）分析其肾皮质的基因表达谱。