Association of immune evasion in myeloid sarcomas with disease manifestation and patients' survival

Myeloid sarcomas (MS) comprise rare extramedullary manifestations of myeloid neoplasms (MN) with poor patients' outcome. While the clinical relevance of the tumor microenvironment (TME) is well established in many malignancies, there exists limited information in MS. Therefore, the expression of the human leukocyte antigen class I (HLA-I) antigens, HLA-I antigen processing and presenting machinery (APM) components and the composition of the tumor microenvironment (TME) were analyzed. RNAseq analysis of a subset of 10 MS patients with preserved and reduced HLA-I HC expression revealed 150 differentially expressed genes in significant reduced expression of inflammatory response genes was found in HLA-I HC high samples. Overall design: Differential expression from HLA-I_high vs HLA-I_low myeloid sarcoma samples