Codon-based test of purifying selection for pair wise analysis between sequences.

Values of p<0.05 were considered significant and tabulated; column [A] shows the number of significant pair wise comparisons. Subjects with SZ showed a 22% increase in the number of synonymous substitutions relative to non synonymous mtDNA substitutions in DLPFC (p = 0.0017).
Column [A] is the number of SNPs by group for purifying selection; column [B] is the number of SNPs by group for neutral selection. The column showing the ratio of [A]/[A+B] is to normalize the purifying SNPs by the total SNPs for the group. The chi-square values are calculated for columns [A] and [B] and for SZ group compared to the control group, there was a higher rate of synonymous substitutions.