Supporting data for "The Healthy Brain Network Serial Scanning Initiative"

Although typically measured during the resting state, a growing literature is illustrating the ability to map intrinsic connectivity in task and naturalistic viewing fMRI paradigms. These paradigms are drawing excitement due to their greater tolerability in clinical and developing populations and because they enable a wider range of analyses (e.g. inter-subject correlations). To be clinically useful, the test-retest reliability of connectivity measured during these paradigms needs to be established. This resource provides data for evaluating test-retest reliability for full-brain connectivity patterns detected during each of four scan conditions that differ with respect to level of engagement (rest, abstract animations, movie clips, flanker task). Data is provided for thirteen participants, each scanned in twelve sessions with 10 minutes for each scan of the four conditions. Diffusion kurtosis imaging data was also obtained at each session.<br>
Technical validation and demonstrative reliability analyses were carried out at the connection-level using the Intraclass Correlation Coefficient (ICC), and at network level representations of the data using the Image Intraclass Correlation Coefficient (I2C2). Variation in intrinsic functional connectivity across sessions was generally found to be greater than that attributable to scan condition. Between-condition reliability was generally high, particularly for the frontoparietal and default networks. Between-session reliabilities obtained separately for the different scan conditions were comparable, though notably lower than between-condition reliabilities. <br>
The described resource provides a test-bed for quantifying the reliability of connectivity indices across conditions and time. The resource can be used to compare and optimize different frameworks for measuring connectivity and data collection parameters such as scan length. Additionally, investigators can explore the unique perspectives of the brains functional architecture offered by each of the scan conditions.<br>
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<b>Funding</b><br>
The Healthy Brain Network and its supporting initiatives are supported by philanthropic contributions from the following individuals, foundations and organizations: Lee Alexander, Lee Alexander, Robert Allard, Lisa Bilotti Foundation, Inc., Margaret Billoti, Christopher Boles, Brooklyn Nets, Agapi and Bruce Burkhard, Randolph Cowen and Phyllis Green, Elizabeth and David DePaolo, Charlotte Ford, Valesca Guerrand-Hermes, Sarah and Geoffrey Gund, George Hall, Joseph Healey and Elaine Thomas, Hearst Foundations, Anton and Robin Katz, Rachael and Marshall Levine, Ke Li, Jessica Lupovici, Javier Macaya, Christine and Richard Mack, Susan Miller and Byron Grote, John and Amy Phelan, Linnea and George Roberts, Jim and Linda , Robinson Foundation, Inc, Caren and Barry Roseman, Zibby Schwarzman, David Shapiro and Abby Pogrebin, Stavros Niarchos Foundation, Nicholas Van Dusen, David Wolkoff and Stephanie Winston Wolkoff and the Donors to the Brant Art Auction of 2012.