Outcomes after ischemic stroke caused by intracranial atherosclerosis versus dissection

Objective To compare the outcomes between patients with non-traumatic intracranial arterial dissection (ICAD) and intracranial atherosclerotic stenosis (ICAS) using high-resolution MRI (HR-MRI).
Methods We conducted a prospective study using HR-MRI in patients with acute symptomatic cerebrovascular disease due to intracranial occlusive disease and no dissection on luminal images. Patients were followed-up for 27.9 ± 19.3 months. We compared the functional outcome, recurrence, and changes in vascular status between patients with ICAD (dissection and no plaque on HR-MRI) and ICAS (atherosclerosis plaque on HR-MRI).
Results We included 312 patients (mean age, 59.0 ± 14.2 years; men, 58.3%), of whom 113 had ICAD and 199 had ICAS. The functional outcome (as measured by modified Rankin score) on the 90th day after symptom onset was not different between the groups, after adjusted for other factors (P = 0.095). However, recurrent ischemic cerebrovascular disease on the relevant vascular terr...