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MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5'UTRs

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NIAID Data Ecosystem2026-05-02 收录
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https://zenodo.org/record/14591947
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MORFEEdb is a  database containing all possible single nucleotide variants (SNVs) creating or altering upORFs(upORF-SNVs).  MORFEEdb was obtained by first performing  a mutational saturation of the 5’UTR of 55 304 transcripts from ~17 000 coding genes where each position in the 5’UTR was in silico mutated withthe 3 alternative nucleotides. The resulting generated VCF files for all transcripts were then annotated with theMORFEE program as described in doi: https://doi.org/10.1101/2024.10.07.616631 The vcf  files resulting from the whole genome 5'UTR mutational saturation are included in the results_per_transcripts.zip archive
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2025-01-06
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