Genome-wide maps of Gata6 in primary mouse keratinocytes

In adult K14?NLef1 mouse, the overexpression of ?NLef1, a ß-catenin dominat negative, in basal keratinocytes leads to the conversion of hair follicles into multilayered epithelial cysts and ectopic sebaceous gland. ?NLef1 transcriptional activity led to Gata6 overexpression in the pilosebaceous unit in transgenic mice. To uncover direct target genes of Gata6 we performed ChIP-Seq experiments in primary mouse keratinocytes. Overall design: Examination of Gata6 genomic targets in mouse primary keratinocytes