Chronic Renal Insufficiency Cohort (CRIC) Study Metabolomics and Proteomics

The Chronic Renal Insufficiency Cohort (CRIC study) was established in 2001 by the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) to improve the understanding of the relationship between chronic kidney disease and cardiovascular disease. The goals of the CRIC Study are to examine risk factors for progression of chronic kidney disease and cardiovascular disease among patients with chronic kidney disease and to develop predictive models to identify high-risk subgroups, informing future treatment trials and increasing application of available preventive therapies. This record includes plasma metabolomics and plasma proteomics data. Genotype data for 3527 CRIC Study partcipants is available at dbGaP in phs000524, "Chronic Renal Insufficiency Cohort (CRIC)-GWAS". Additional phenotypic, clinical, and outcomes data are available at the NIDDK Central Repository and can be linked to data available at dbGaP.More than 330 manuscripts have been published, reporting on the effects of a broad range of risk factors (from molecular biomarkers of disease pathways to clinical, demographic, and behavioral characteristics) on the progression of CKD and other health consequences. The full CRIC bibliography can be found at the BIBLIOGRAPHY for the Chronic Renal Insufficiency Cohort (CRIC) Study.]]>
Participants are no longer being enrolled in the study. The following Inclusion/Exclusion Criteria were followed at the time of participant recruitment. Inclusion for participants enrolled in phase 1: Age, 21 to 74 years Age Based eGFR: 21-44 years, 20-70 ml/min/1.73m2 45-64 years, 20-60 ml/min/1.73m2 65-74 years, 20-50 ml/min/1.73m2 Exclusion: Institutionalized Unable or unwilling to provide informed consent Participant appears unlikely or unable to participate in the required study procedures as assessed by the investigator, study coordinator or designee NYHA Class III or IV heart failure at baseline Known cirrhosis based on patient self-report, known ADPKD, known HIV infection and/or AIDS based on patient self-report Present participation in the AASK Cohort Study Pregnant women ]]>
2001: design of the study began2004-2008: recruitment of participants conducted resulting in over 3000 enrolled participants2008: phase 2 of the study began, follow-up of cohort2013: Phase 3 of the study began, new recruitment and continued follow-up of the existing cohort2013- 2015: Recruitment of Phase 3 cohort (n=1560 additional participants)2018: Phase 4 of the study began, continued follow-up of the cohort2023: Phase 5 of the study began, participant follow-up extended for 3 additional years]]>