Memory-enhancing effects of Origanum majorana essential oil in an Alzheimer's amyloid beta1-42 rat model: a molecular and behavioral study

Origanum L. (Lamiaceae) is an important genus of medicinal and aromatic plants used in the traditional medicine since ancient times as culinary herbs and remedies. The effects of Origanum majorana-based aromatherapy was investigated in an Alzheimer's amyloid beta1-42 rat model. Protein extracts from brain tissue containing hippocampi were analyzed by label-free quantitative LC-HDMSE. Proteins whose expression seemed influenced by Origanum majorana-based aromatherapy were assigned as representatives of biological processes, which were further targeted using well established biochemical/molecular assays.