Proportion of surviving pups and their sex ratios in relation to dose and parental treatment.

Proportion of surviving pups was determined while weaning the pups at age 4 weeks.ZDV = Zidovudine; NVP = Nevirapine.aFour males from each dose mated five females each to give a total of twenty dams per dose. Ten of these dams were untreated (“father-only” treated groups) while the other ten had received the same dose as the males (“both-parents” treated groups) for 56 days before mating. Harem mating was done by co-housing one male and five females for 10 days without checking for vaginal plugs.bWe compared the survival proportion of the treatment groups to that of the untreated control group (70.8%) using the binomial test. The proportions of surviving pups were significantly different for most treatment groups except for that of the ZDV 100 mg/kg at both first and repeat mating; for NVP 50 mg/kg at first mating and for NVP 150 mg/kg at repeat mating.Proportion of surviving pups and their sex ratios in relation to dose and parental treatment.