S-phase checkpoint prevents leading strand degradation from strand-associated nicks at stalled replication forks
收藏NIAID Data Ecosystem2026-05-01 收录
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Our goal was to examine the enzymology of DNA replication during a single S-phase in the presence of replicative stress through PU-seq and GLOE-seq methodologies. Our data reveal an unexpected role of Exo1 at the leading strand and support a model of fork stabilization through prevention of unrestrained Exo1-dependent resection of leading strand-associated nicks after fork stalling.
创建时间：
2024-03-08
