Gene expression profile of Aggressive NK cell Leukemia (ANKL) cells in liver and spleen microenvironments. Gene expression profile of Aggressive NK cell Leukemia (ANKL) cells in liver and spleen microenvironments

In patient-derived xenograft (PDX) mouse, ANKL cells actively proliferate in liver, compared with spleen. We use single cell RNA sequencing (scRNA-seq) to analyze the diversity of ANKL cells in liver and spleen Overall design: Human-CD45+ ANKL cells were isolated from liver and spleen of ANKL-PDX mice by magnetic cell sorting (MACS), and analyzed using scRNAseq.