Pharmacology of the T618I hERG mutant studied with action potential voltage clamp.

IC50 and nH values shown are derived from fits to concentration-response relations in Figure 7, obtained from fractional inhibition of IhERG using a voltage step protocol (shown in Figure 7A). Columns show mean values and 95% confidence intervals (C.I). The right-hand column expresses the ratio of the T618I IC50 to the WT IC50 value, to one decimal place. The numbers in parentheses in the right hand column represent the range of ratio values for the ± C.Is for derived T618/WT IC50s.