Blocking MAIT cell activation can modulate macrophage gene signature during liver fibrosis regression. Blocking MAIT cell activation can modulate macrophage gene signature during liver fibrosis regression

Exploratory RNA sequencing of pro-inflammatory (Ly6C high) and resolutive (Ly6C low) macrophages in mouse liver during fibrosis regression. Mice were treated with a MAIT antagonist or its control vehicle for 2 days after the last CCl4 injection. Ly6C high and Ly6C low macrophages were sorted by ARIA III. Overall design: Pro-inflammatory and resolutive macrophage gene signature profile during liver fibrosis regression when MAIT cells are inhibited.