High dimensional immunotyping of the obese tumor microenvironment with unanchored batch correction
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http://flowrepository.org/id/FR-FCM-Z32G
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资源简介：
Analysis of tumor immune infiltrate in immunocompetent mice with orthotopic syngeneic tumors. This experiment contains 57 fcs files of CD45+ tumor immune infiltrate from 7 CyTOF batches across 5 tumor models in obese and non-obese settings. Files have been normalized and debarcoded. Arcsinh transformation and unanchored cydar range batch correction has been applied to channels with the "c_" prefix. Original channels are present in the files. viSNE tSNE coordinates are also present.
Conclusion:
Unanchored range-based batch correction using cydar in R was successful and enabled the simultaneous analysis of 7 different CyTOF batches. bioRxiv: https://doi.org/10.1101/2020.10.14.338806
Notes:
Breast cancer models: E0771 (2 batches), Wnt1, TeLi Pancreatic cancer: C11 (2 batches), UN-KC High fat diet fed/obese mice: H Standard chow diet/non-obese mice: C Helios CyTOF, Narrow bore (HT) injector Data Normalization
创建时间：
2021-12-01
