Proteome Turnover in Bloodstream and Procyclic form Trypanosoma brucei Measured by Quantitative Proteomics

Cellular proteins vary significantly in both abundance and turnover rates. These parameters depend upon their rates of synthesis and degradation and it is useful to have look-up data on protein turnover rates when, for example, designing genetic knock-down experiments or assessing the potential usefulness of covalent enzyme inhibitors. Little is known about the nature and regulation of protein turnover in Trypanosoma brucei, the etiological agent human and animal African trypanosomiasis.