Homo sapiens Transcriptome or Gene expression. Homo sapiens

Transient receptor potential melastatin 5, TRPM5 has recently emerged as a potent regulator of hair growth, and according to some evidence, it may also be expressed in the adjacent sebaceous glands. This means that TRPM5 modulators administered with the intention of influencing hair growth may also have an unintended impact on sebaceous gland functions. Because such interactions may theoretically give rise to severe side effects, including iatrogenic acneiform eruptions or skin dryness, in the current study, we aimed to investigate the biological effects of triphenylphosphine oxide, a TRPM5 antagonist, on human SZ95 sebocytes.