Up-regulated miRNAs with predicted YY1 binding sites on promoter.

Genome-wide computational prediction reveals the prevalence of YY1 binding sites on promoters of miRNAs. C2C12 myoblasts were grown in growth medium (GM) or differentiated in differentiation medium (DM) for 3 days. Total RNAs were extracted and subjected to expression profiling using a microarray platform. 77 miRNAs were found to be up-regulated in DM compared to GM with a fold change (DM/GM) more than 2. These miRNAs were run through the YY1 binding site search pipeline. A total of 30 miRNAs were found to contain at least one YY1 binding site on their promoters.