Single-cell sequencing reveals age-induced hematopoietic immune system cell changes and pro-inflammatory changes (PRJCA019290)

We here applied scRNA-seq to comprehensively characterize the properties of hematopoietic and immune organs cells in young (2-3 week) and old (20-22 month) mice. By performing scRNA-seq, we found that aging alters the composition of cell subsets, gene expression characteristics, enrichment pathways, transcriptional regulatory networks, and intercellular interactions, resulting in a pro-inflammatory state of the body. These findings provide a comprehensive landscape of the effects of aging on the hematopoietic system and expand our understanding of aging as a risk factor for inflammation, autoimmune diseases, and aging-related disorders.