TET2 regulates the neuroinflammatory response in microglia

Epigenetic mechanisms regulate distinct aspects of the inflammatory response in various immune cell types. Despite a central role for microglia in neuroinflammation and neurodegeneration little is known about their epigenetic regulation of the inflammatory response. We found that TET2 expression is increased in microglia upon stimulation with various inflammogens through a NF-kB-dependent pathway. RNA-seq analysis showed that TET2 modulates the transcriptional response of microglial cells to LPS. Overall design: TET2-depleted or control microglial BV2 cells were treated with LPS for 3 hours.