Supplementary Materials for manuscript “Comparative genomics of three non-hematophagous leeches (<i>Whitmania</i> spp.): focusing on antithrombotic genes”

Leeches are well known for their blood-feeding habits and are widely used for medicinal purposes as they secrete various antithrombotic substances. However, some leeches such as <i>Whitmania</i> spp. exhibit non-hematophagous feeding habits and their significance for medicinal use is debated. Here, we provide two nearly complete high quality genomes of <i>Whitmania acranulata</i> and <i>Whitmania laevis</i>. We also identified many antithrombic gene families involved in anticoagulation, anti-platelet aggregation, fibrinolysis, and drug diffusion. Our results will greatly facilitate the evolutionary research and application of leech derivatives for medical and pharmaceutical purposes of thrombosis.File_S1_Wacr.genome.zip: Supplementary File S1, the genome assembly of W. acranulata.File_S2_Wlae.genome.zip: Supplementary File S2, the genome assembly of W. laevis.File_S3_Wacr.gff.zip: Supplementary File S3, the GFF file of W. acranulata.File_S4_Wlae.gff.zip: Supplementary File S4, the GFF file of W. laevis.File_S5_Wacr.anti.fas: Supplementary File S5, coding sequences of all antithrombotic genes of W. acranulata.File_S6_Wlae.anti.fas: Supplementary File S6, coding sequences of all antithrombotic genes of W. laevis.