Time-dependent gene expression patterns in injured brains of WT and LRRK2 G2019S mice.

The effects of the LRRK2 G2019S (GS) mutation on brain injury and recovery from injury were examined by comparing time-dependent gene expression patterns in injured brains of WT and GS mice, beginning 6 h after injury to almost complete repair 15 days later. Brain injury was induced by stereotaxic injection of ATP, a component of damage-associated molecular patterns (DAMPs), into the striatum. We performed gene expression profiling analysis using data obtained from RNA-seq of injured brains of WT and LRRK2 G2019S mice at 4 time points.