Case-control association analysis in cohort Ia. The best SNPs in genes associated with lupus nephritis with p <0.001 are shown.

The best SNP in each gene is shown and for STAT4, IRF5, TNIP1 and BLK also the SNPs used for meta-analysis, marked in bold; STAT4 rs11889341, rs7582694 r2 = 0.98, IRF5 rs2070197, rs10488631 r2≈1.00, TNIP1 rs7708392, rs6889239 r2≈1.00 and BLK rs922483, rs13277113 r2 = 0.87 calculated in 512 Swedish controls. OR: odds ratio, CI: confidence interval, NA: not available.a Uppsala, Stockholm and Lund, Sweden, n = 567 SLE cases, n = 512 controlsb WHO class III or IV on renal biopsy, according to the 1995 WHO classification system [2].c Glomerular filtration rate 2[22].d rs3135394 has an r2 = 0.87 with the HLA*DR3 (DRB1*0301) allele [6].e Unadjusted p-value and OR for differences in allele frequencies between patients and controls.f Adjusted p-value and OR from logistic regression analysis including age and gender as covariates. Number of cases and controls; lupus nephritis, n = 194, proliferative nephritis, n = 91, severe renal insufficiency, n = 28, SLE, n = 566, controls, n = 504.