Cholesteryl Ester Transfer Protein (CETP) as a Drug Target for Cardiovascular Disease

Contains data and computer scripts to generate the figures underlying the manuscript: Cholesteryl Ester Transfer Protein (CETP) as a Drug Target for Cardiovascular Disease.The README.md:# Scripts and deposited data This directory contains R and python scripts along with the data necessary to generate the results described in the manuscript: 'cholesteryl ester transferprotein (CETP) as a drug target for cardiovascular disease'. ## Directory content .├── README.md├── scripts├── figures├── MR_data├── TRIAL_data└── PICKLED_dataThe `scripts` directory contains the computer codes necessary to generate the figures which get saved to the `figures` directory.The scripts source data from the `MR_data` and `TRIAL_data` directories. The `PICKLED_data` directory contains the python pickled files from which we extracted the .csv files in `MR_data` -- these files can be ignored. ## Computer scriptsThe directory root contains various R (.R) and python (.py) scripts that will process the data files. It also contains a `cetp_conda_env.yml` file to conda install the necessary R and python modules:```cd scriptsconda env create -f cetp_conda_env.yml ```This creates the `cetp` conda environment. To generate the figures, please run the following `bash` script:```# run from the scripts directory./run_scripts.sh```### Input and output* scripts/MR_heatmap.py: Takes the MR_data .tsv files and returns Figures 2 and 5.* scripts/MR_metabolites.R: Takes the MR_data .tsv/csv files and returns Figure 4.* scripts/MR_forestplots.R: Takes the MR_data .tsv files and returns Figure 3.* scripts/RCT_forestplots.R: Takes the TRIAL_data .xlsx files and returns Figure 1.## ContactPlease contact Floriaan Schmidt for any queries: [e-mail] .

本数据集包含生成论文《胆固醇酯转移蛋白（CETP）作为心血管疾病治疗靶点》所依托图表所需的数据和计算机脚本。README.md文件中详述了脚本和存档数据：

# 脚本与存档数据
本目录内含R和Python脚本，以及生成论文《胆固醇酯转移蛋白（CETP）作为心血管疾病治疗靶点》中所述结果的必要数据。

## 目录内容
.├── README.md
├── scripts
├── figures
├── MR_data
├── TRIAL_data
└── PICKLED_data

`scripts`目录存储了生成保存至`figures`目录中图表所需的计算机代码。脚本从`MR_data`和`TRIAL_data`目录中提取源数据。
`PICKLED_data`目录包含从其中提取了`MR_data`中的.csv文件的Python pickled文件，这些文件可忽略。

## 计算机脚本
目录根包含处理数据文件的多种R（.R）和Python（.py）脚本，同时包含一个`cetp_conda_env.yml`文件，用于conda安装必要的R和Python模块：
bash
cd scripts
conda env create -f cetp_conda_env.yml

这将创建`cetp` conda环境。要生成图表，请在`scripts`目录下运行以下bash脚本：
bash
# 从scripts目录运行./run_scripts.sh

### 输入与输出
* scripts/MR_heatmap.py：接收MR_data的.tsv文件，生成图表2和5。
* scripts/MR_metabolites.R：接收MR_data的.tsv/csv文件，生成图表4。
* scripts/MR_forestplots.R：接收MR_data的.tsv文件，生成图表3。
* RCT_forestplots.R：接收TRIAL_data的.xlsx文件，生成图表1。

## 联系方式
如有任何疑问，请联系Floriaan Schmidt：[e-mail]。