Nickel-Catalyzed Enantioselective Reductive Aryl Fluoroalkenylation of Alkenes

Enantioselective
Ni-catalyzed reductive aryl monofluoroalkenylation
of alkenes between aryl bromides and gem-difluoroalkenes
has been developed. The reaction proceeding under room temperature
and base-free reaction conditions tolerates a wide range of functional
groups on both coupling partners. Various synthetically useful oxindoles
containing monofluoroalkenyl substituent are obtained in good yields
with 85%–95% enantiomeric excess. In addition, the synthetic
method can be further applied to the late-stage monofluoroalkenylation
of complex biologically active compounds.