Evaluation of Novel Cell Repair Compounds as Potential Treatments for Chronic Obstructive Pulmonary Disease (COPD)

This thesis evaluated the therapeutic effects of various AusBio Ltd-developed novel cell repair (MD990) compounds, as potential treatments for chronic obstructive pulmonary disease (COPD), in a cigarette smoke-induced murine model of COPD. The completed studies provide for the first time, a demonstrated link between the restoration of sialic acid expression levels within the airway epithelium (by these compounds) to the reduction or attenuation of various COPD-related pathologies and dysfunction that results from prolonged cigarette smoke exposure. Hence, this thesis has identified that sialic acid restoration may be a novel therapeutic strategy for treating COPD.