1,2-Benzisothiazole Derivatives Bearing 4‑, 5‑, or 6‑Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions
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https://figshare.com/articles/dataset/1_2-Benzisothiazole_Derivatives_Bearing_4_5_or_6_Alkyl_arylcarboxamide_Moieties_Inhibit_Carbonic_Anhydrase_Isoform_IX_CAIX_and_Cell_Proliferation_under_Hypoxic_Conditions/3464663
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资源简介：
Three novel series of 1,2-benzisothiazole
derivatives have been
developed as inhibitors of carbonic anhydrase isoform IX. Compounds 5c and 5j, tested in vitro on the human colon
cell line HT-29, blocked the growth of cells cultured under chemically
induced hypoxic conditions, displaying a specific activity against
cancer cells characterized by CAIX up-regulation. Moreover, a synergistic
activity of 5c with SN-38 (the active metabolite of irinotecan)
and 5-fluorouracil on cell proliferation under hypoxic conditions
was demonstrated.
创建时间：
2016-07-08
