Transcriptional characterisation of mouse embryonic stem cell differentiation in response to graded Wnt stimulation.

Pluripotent stem cells, including embryonic stem cells hold tremendous potential for regenerative medicine as a cell source to model disease or in a transplantation setting. However, in order to effectively derive the desired target cell types, we need to understand the role of basic signalling pathways early in this fundamental process. In the context of the current study we investigated the function of graded Wnt signalling in directing either differentiation or promoting self-renewal molecular.