Multiplex IgG antibody response and malaria parasitemia among children ages 1-59 months in the MORDOR Niger trial, 2015-2018

We measured IgG responses to several malaria, bacterial, and protozoan pathogens using a multiplex bead assay in pre-specified substudy of 30 communities in the rural, MORDOR Niger placebo-controlled trial over a three-year period (n=5,642 blood specimens, n=3,814 children ages 1-59 months). We compared seroprevalence and serological force of infection between 15 communities that received biannual mass distribution of azithromycin versus placebo. The study included antigens to: Plasmodium falciparum (MSP-1, AMA1, GLURP-Ro, LSA1, CSP, HRP2), P. vivax (MSP-1), P. ovale (MSP-1), P. malariae (MSP-1), Campylobacter jejuni (p18, p39), enterotoxigenic Echerichia coli ( ETEC LTB), Vibrio cholerae (CTB), Salmonella enterica (LPS serogroups B, D), Cryptosporidium parvum (Cp17, Cp23), Giardia duodenalis (VSP-3, VSP-5), and Streptococcus group A (SPEB).