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PRDM16 deficiency triggered by TGF-β1 signaling promotes aberrant mitochondrial homeostasis and kidney fibrosis

NIAID Data Ecosystem2026-05-02 收录

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线粒体稳态失调

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241047 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-08-12

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受体信号通路

Liver fibrosis is a reversible wound-healing response to liver injury and hepatic stellate cells (HSCs) are central cellular players that mediate hepatic fibrogenesis. However, the molecular mechanism

NIAID Data Ecosystem120

A Ribosomal S-6 Kinase–Mediated Signal to C/EBP-β Is Critical for the Development of Liver Fibrosis

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RSK-C/EBPβ信号通路

BackgroundIn response to liver injury, hepatic stellate cell (HSC) activation causes excessive liver fibrosis. Here we show that activation of RSK and phosphorylation of C/EBPβ on Thr217 in activated

NIAID Data Ecosystem40

RNA-seq of fibrotic liver tissues from CCL4-induced mice. Mus musculus strain:C57/BL6

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RNA测序分析

To investigated the role of CD73 in liver fibrosis, RNA-sequencing of fibrotic liver tissues from CCL4-induced mice were performed. Three groups (three mice for each group) were included in this study

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Structure of NNQQNY as an insert in T7 endonuclease I

蛋白质结构解析

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Structure of NNQQNY as an insert in T7 endonuclease I Descriptor: Endonuclease I Authors: Guo, Z, Eisenberg, D. Deposit date: 2008-02-19 Release date: 2008-07-22 Last modified: 2023-08-30 Method: X-RA

Protein Data Bank Japan2023-08-30 更新90

miR-452-5p mediates SCN5A dependent fibrosis via TGF-beta/SMAD4 axis

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TGF-β信号通路

SCN5A coding for sodium channels in the heart and its reduced activity implicated various biological processes including fibrogenesis. However, the mechanistic interplay between loss of SCN5A activit

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PRDM16 deficiency triggered by TGF-β1 signaling promotes aberrant mitochondrial homeostasis and kidney fibrosis

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