Significantly enriched GO terms in heart jogging genes in zebrafish and their human and mouse orthologs

Zebrafish data: GO terms significantly enriched in zebrafish ‘heart jogging’ gene list. The GO biological process, molecular function and cellular component terms that are highly enriched in the zebrafish ‘jogging’ gene list. The GO terms are listed in order of decreasing p-values and the ‘universe set’ size included in the functional analysis using VLAD is 14,577.
Human data: GO terms significantly enriched in human orthologs of zebrafish ‘heart jogging’ genes.The GO biological process, molecular function and cellular component terms that are highly enriched in the human ‘jogging ortholog’ gene list. The GO terms are listed in order of decreasing p-values and the ‘universe set’ size included in the functional analysis using VLAD is 30,441.
Mouse data: GO terms significantly enriched in mouse orthologs of zebrafish ‘heart jogging’ genes.The GO biological process, molecular function and cellular component terms that are highly enriched in the mouse ‘jogging ortholog’ gene list. The GO terms are listed in order of decreasing p-values and the ‘universe set’ size included in the functional analysis using VLAD is 24,813.
Biological process summary: Summary of all enriched biological process GO terms across all three species. The enriched biological process GO terms are grouped into general biological areas (‘development’, ‘patterning’, ‘cellular process’, ‘signaling’, ‘movement’ and ‘high level terms’, text in upper case). Each area is subdivided into more specific ontologies, based on the Gene Ontology structure. A subset of the biological process GO terms and data are reported in Table 2 in the main article. High-level terms were not included in any further discussion, as these terms are not specific enough to be informative. k: the number of genes in each gene list annotated to the GO term; M: the number of genes in the species proteome annotated to the GO term. Starred genes are annotated directly to the enriched term. Non-starred genes are annotated to a ‘child’ of the enriched term. DAR: zebrafish, HUM: human, MUS: mouse.
Mouse gene list:‘Early heart development’ mouse gene list. The evidence that these 103 mouse genes have a role in the early stages of heart development comes from their orthology to the zebrafish ‘heart jogging’ gene list, from phenotypes associated with specific genotypes, or annotation to the GO term ‘determination of heart left/right asymmetry’ or it’s child terms (see method section in main article for full details).

斑马鱼数据集：在斑马鱼‘心脏跑步’基因列表中显著富集的 GO 术语。包括在斑马鱼‘跑步’基因列表中高度富集的 GO 生物过程、分子功能和细胞组分术语。GO 术语按 p 值递减的顺序排列，并使用 VLAD 进行功能分析时所包含的‘全宇宙集’的大小为 14,577。
人类数据集：在人类与斑马鱼‘心脏跑步’基因同源基因中显著富集的 GO 术语。包括在人类‘跑步同源’基因列表中高度富集的 GO 生物过程、分子功能和细胞组分术语。GO 术语按 p 值递减的顺序排列，并使用 VLAD 进行功能分析时所包含的‘全宇宙集’的大小为 30,441。
小鼠数据集：在小鼠与斑马鱼‘心脏跑步’基因同源基因中显著富集的 GO 术语。包括在小鼠‘跑步同源’基因列表中高度富集的 GO 生物过程、分子功能和细胞组分术语。GO 术语按 p 值递减的顺序排列，并使用 VLAD 进行功能分析时所包含的‘全宇宙集’的大小为 24,813。
生物过程概述：对三个物种中所有富集的生物过程 GO 术语的总结。富集的生物过程 GO 术语被归类于一般的生物学领域（‘发育’，‘模式形成’，‘细胞过程’，‘信号传导’，‘运动’和‘高级术语’，文本为全大写）。每个领域根据基因本体结构进一步细分为更具体的本体。主文章中的表格 2 报道了生物过程 GO 术语和数据的一个子集。高级术语未包含在进一步的讨论中，因为这些术语不足以提供信息。k：注释到 GO 术语的每个基因列表中的基因数量；M：注释到物种蛋白质组中的 GO 术语的基因数量。带有星号的基因直接注释到富集术语。非星号基因注释到富集术语的‘子’术语。DAR：斑马鱼，HUM：人类，MUS：小鼠。
小鼠基因列表：‘早期心脏发育’小鼠基因列表。这些 103 个小鼠基因在心脏发育早期阶段发挥作用的证据来自它们与斑马鱼‘心脏跑步’基因列表的同源性，与特定基因型的表型相关，或注释到 GO 术语‘心脏左右不对称的决定’或其子术语（详见主文章中的方法部分以获取详细信息）。