The phosphatase regulator NIPP1 controls epidermal homeostasis

To delineate the in vivo function of NIPP1 in epidermal homeostasis, we generated skin-specific NIPP1 knockout (SKO) mice where NIPP1 is conditionally removed from keratinocytes. To gain unbiased insight into the molecular mechanism that underlies the hyperproliferation phenotype, we performed RNA-seq of the isolated epidermis of control (CTR) and SKO mice. We extracted RNA from tail epidermis of 4 CTR and 4 SKO mice and performed RNA-seq on each sample.