K6-Linked Ubiquitylation Signals Reactive Aldehyde-Induced RNA-Protein Crosslink Resolution
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https://www.ncbi.nlm.nih.gov/sra/SRP454551
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资源简介：
Reactive aldehydes induce the formation of RNA-protein crosslinks (RPCs), RPCs in the mRNA stall the ribosome and inhibit translation, RPCs are K6-linked ubiqutylated by RBR-type E3 ligase RNF14, RPCs are resolved in a UBXN1-VCP/p97-dependent manner Overall design: Proteome-wide iCLIP to detect the distribution of RPC across RNAs; RPCs were introduced with 5 uM 4sU + 0.5 J/cm² UVA (365 nm); protein cleanup with SP3 beads; 2 replicates
创建时间：
2025-12-09
