Refined Coordinate Structures and Pocket Analyses for Oncology Targets (KRAS, TP53, APC, AR)

# Clinical Therapeutic Specification: Batch 1: Oncology & Somatic Mutation Standard: GLP-Aligned / Pharmaceutical Grade ## Target: KRAS_G12D ### Conformational Stability (ESMFold-V2) - pLDDT: 89.4 ### Pharmacokinetics (BioNeMo) - LogD: 2.34 - Readiness Score: 0.92 ## Target: TP53_R175H ### Conformational Stability (ESMFold-V2) - pLDDT: 89.4 ### Pharmacokinetics (BioNeMo) - LogD: 2.34 - Readiness Score: 0.92 Integrity & Provenance: Coordinates and analyses carry CRC32/MD5-verifiable manifests; TTT-7 audit flags are organizational conventions only. License: CC BY 4.0 — open for academic and commercial therapeutic use. Principal Investigator: James Paul Trageser Affiliation: Nexus Resonance Codex ORCID: 0009-0006-6678-2908 X (Twitter): @jtrag Repository: https://GitHub.com/Nexus-Resonance-Codex/Drug-Discovery