Grm4-mediated glutamatergic signaling reshapes the TME by regulating dendritic cell maturation (PRJCA028822)

Metabotropic glutamate receptor 4 (mGluR4, encoded by Grm4), traditionally associated with neuronal signaling, has been identified as a pivotal player in immune modulation. To gain a comprehensive understanding of the effect of Grm4 on the liver TME, we sorted 8,000 intratumoral CD45.2+ immune cells from five tumors that had been growing in Grm4-/- or WT mice and performed single-cell RNA sequencing.