Gene expression profiling of Jun -/- and Jun +/+ facial motor neurons

To determine target genes, biological functions of Jun and mechanisms of gene regulation by Jun in regenerating neurons, gene expression profiling was carried out of axotomized and uninjured facial motor neurons in floxed c-Jun mice crossed with nestin-cre mice. Nestin-promoter-driven Cre ensures deletion of Jun in the central nervous system including facial motor neurons. KO animals were Jun Flox/Fox Cre+, while WT animals were Jun Flox/Flox, Cre-. At 1 day, 4 days and 14 days after facial nerve injury and in uninjured animals, gene expression profiles of facial nuclei were determined in KO and WT mice. US12302316_251486819468_S01_GE2-v5_95_Feb07_1_4.txt