A dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

ChEBI2014-10-17 更新2026-07-21 收录

核受体信号转导

代谢性肝病机制

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A dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

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2014-10-17

Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with a Dynamic Oxime-derivative

蛋白-配体结构解析

核受体信号转导

Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with a Dynamic Oxime-derivative Descriptor: 2-chloro-3'-fluoro-3-[(E)-(hydroxyimino)methyl]biphenyl-4,4'-diol, Estroge

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T cell antigen receptor (TCR) signaling controls the development, activation and survival of T cells by involving several layers and numerous mechanisms of gene regulation. N6-methyladenosine (m6A) is

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Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

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代谢性肝病机制

In rodents, brown adipose tissue (BAT) contributes to whole body energy expenditure and low BAT activity is related to hepatic fat accumulation, partially attributable to the gut microbiome. Little is

NIAID Data Ecosystem30

Structural basis for the asymmetric binding of coactivator SRC1 to FXR-RXRα and allosteric communication within the complex

核受体信号转导

代谢物-蛋白相互作用

Structural basis for the asymmetric binding of coactivator SRC1 to FXR-RXRα and allosteric communication within the complex

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代谢性肝病机制

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High-carbohydrate diet (HCD) is a significant nutritional factor inducing metabolic dysfunction-associated steatotic liver disease (MASLD). The core mechanism involves metabolic dysregulation and cell

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A dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

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