topoSNP

The database of topographic mapping of Single Nucleotide Polymorphism (topoSNP) provides an online resource for analyzing missense SNPs that can be mapped onto known 3D structures of proteins. These include disease- associated missense SNPs derived from the Online Mendelian Inheritance in Man (OMIM) database and other missense SNPs derived from dbSNP, a resource at the National Center for Biotechnology Information that catalogs SNPs.单核苷酸多态性（Single Nucleotide Polymorphism, SNP）地形图谱数据库（topoSNP）为可映射至已知蛋白质三维结构的错义单核苷酸多态性分析提供了在线资源。该数据库收录的错义单核苷酸多态性包含两类：一类为源自人类在线孟德尔遗传（Online Mendelian Inheritance in Man, OMIM）数据库的疾病相关错义单核苷酸多态性，另一类为源自美国国家生物技术信息中心（National Center for Biotechnology Information, NCBI）运营的单核苷酸多态性收录数据库（dbSNP）的其余错义单核苷酸多态性。

搜集汇总

背景与挑战

背景概述

topoSNP是一个专注于单核苷酸多态性（SNP）地形映射的数据库，提供在线工具以分析可映射到蛋白质3D结构的错义SNP。它整合了来自OMIM的疾病相关SNP和来自dbSNP的其他SNP数据，支持通过多种标识符进行查询。